Mechanisms of Angina Pectoris in Syndrome
نویسنده
چکیده
Syndrome Xdefines a group of patients who present with typical, usually exertional angina pectoris and a normal coronary arteriogram. They often have a positive exercise test, but direct signs of ischemia are detectable in only a minority of patients. Areduced coronary vasodilative response to dipyridamole or pacing is observed in such patients with or without a positive electrocardiographic exercise test. It is proposed that patients with syndrome X have a patchily distributed abnormal constriction of coronary prearteriolar vessels not involved in metabolic autoregulation of flow. An increased resistance of prearteriolar vessels can explain the reduced coronary vasodilative response observed in these patients, even when arterioles dilate maximally. Distal to the most constricted arterioles a localized compensatory increase of adenosine concentration can cause angina even in the absence of
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تاریخ انتشار 2016